Van Horn. Hwy 54 connects Van Horn and the Guadalupe Mountains National Park, and is a wonderfully scenic ride and drive.
Van Horn is also the home of the historic Hotel El Capitan, one of our Texas Mountain Trail cycle-friendly hotels. Here's a link to their website. You can read more about regional cycling opportunities and cycle-friendly hotel options on the Texas Mountain Trail website: http://www.texasmountaintrail.com/bike